Kyprolis ® (carfizomib)

●      Brand Name:Kyprolis ®

●      Generic name: carfizomib

●     Uses: Treatment of multiple myeloma (cancer of a type of white blood cell that produces antibodies that helps fight infection)

●     How it works: Inhibits cancer cell growth

●     Most common side effects: Swelling of the arms and legs, constipation, diarrhea, nausea, vomiting, low white and red blood cell count, backache, headache, cough, difficulty breathing, tiredness, fever

●     Serious side effects: Heart failure, heart attack, kidney failure, low white blood cell count

●     Who cannot use this medication: Have not yet been determined

●     Dose: Available as 60 mg/vial

○     Inject 20 mg/m²/day over 2 to 10 minutes on days 1,2, 8, 9, 16 followed by a 12 days with no medication (days 17-28)

○     Can repeat dose again during next 28 days or increase dose to 27mg/m²/day

●     Package Insert: http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/202714lbl.pdf

●     Reference: Micromedex Web site. http://www.thomsonhc.com.proxy.pba.edu/. Accessed October 2, 2012.